GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs904251 | 1 | rs12212090 | chr6:37431808 | C6orf129 | chr6:37450699-37467700:- | 0.12 | 4.67 | 3.37E-6 | Cognitive performance |
| BRCA | cis | rs904251 | 1 | rs12212090 | chr6:37431808 | RNF8 | chr6:37321748-37362513:+ | 0.12 | 3.61 | 0.000316 | Cognitive performance |
| BRCA | cis | rs12196860 | 1 | rs12212135 | chr6:55965006 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12212143 | chr6:55965055 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12212211 | chr6:55995226 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.82 | 1.48E-11 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12212733 | chr6:86726013 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.19 | 1.31E-64 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12213149 | chr6:86668644 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -18.94 | 3.26E-69 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12213291 | chr6:55957074 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12213434 | chr6:159369128 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12196860 | 1 | rs12213571 | chr6:55957493 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12213740 | chr6:86656733 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -17.89 | 8.03E-63 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12214519 | chr6:55966884 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.81 | 1.58E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12214594 | chr6:56010824 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.83 | 1.44E-11 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12214813 | chr6:159362013 | RSPH3 | chr6:159398268-159421198:- | 0.21 | 3.79 | 0.000157 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs12214878 | chr6:159362118 | RSPH3 | chr6:159398268-159421198:- | 0.21 | 3.79 | 0.000157 | Bladder cancer (smoking interaction) |